Steam Community :: Guide :: Detailed all achievements (Dead God/Infinity) route for Repentance+

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Credits

The original author of this route is the very popular content creator Thereisnofuture.

As of now - April 2026 - he is the world record holder:

for the Dead God speedrun in Repentance (96 hours 12 minutes 50 seconds)
for the 4-goals Eden streak (2000)

Link to his speedrun profile [www.speedrun.com]
Link to his twitch channel [www.twitch.tv]

I am not affiliated with him in any way.

Important notes and links

This guide is not intended for complete beginners. It's recommended to have at least some minimal hours - around 100 - since neither the author nor I explain basic things.

The original route is written in Russian, so if you speak the language and got Dead God at least 1 time, perhaps it's better to refer to the original file - although I have added a lot of commentary in my guide:

Link to the original route[docs.google.com]

If you don't speak Russian but consider yourself a really experienced player who doesn't need extensive explanations, I've done my best to translate the original route into English:

Link to the translated version of the route[docs.google.com]

Here is the actual execution of this route as well as the world record run made by the author for Repentace. Please note, the route was slightly different:

Repentance speedrun

A more recent, non-serious speedrun attempt in Repentance+ (93 hours 29 minutes 22 seconds) for testing purposes while following this route:

Repentance+ speedrun, the first stream[www.twitch.tv]
Repentance+ speedrun, the last stream[www.twitch.tv]

You can find the rest in the “Past Broadcasts.” When he uploads this speedrun to YouTube, I'll update the link if I remember.

How to read this guide

The original file consists of introduction notes, route steps and notes for each step.

The original introduction notes are shown in quote boxes:
Originally posted by Thereisnofuture:
Main updates in Rep+: the Portal to the Void is now guaranteed
The original route steps are shown as section titles:
Isaac - Sheol
The original notes for each step are shown in quote boxes:
Originally posted by Thereisnofuture:
The first run is just Isaac on Hard mode.

The rest of the text is my commentary.

Introduction notes

Originally posted by Thereisnofuture:
This route is an attempt to complete The Binding of Isaac: Repentance+ without resets and with a minimum number of deaths. You can also use it for speedruns (though not for infinite Clicker+Rkey strategies) because substantially the goal is the same, except some minor differences. The route isn't and doesn't try to be either the best or the most efficient one but rather author's personal vision of an optimal walkthrough.
To track some achievements in real time, you can use IsaacAchievementTracker - created by https://www.twitch.tv/po4ti__ -> Download link: https://www.mediafire.com/file/80s7btqhoowsiml.

I myself didn't use the suggested software. I tracked everything in my excel file. I also created a template that you can use for your own runs.

It includes "How to use" and "Example" sheets. The Example sheet contains real runs from my third Dead God playthrough, following this route.

Runs example:

Unlocks example:

I've uploaded it to Google Sheets, feel free to use it:
Link to tracking table[docs.google.com]

Another useful resource I came across online:
https://deadgod.yeeterie.org
It is very helpful for tracking missing items. I didn't use it myself because I discovered it later but I would definitely use it.

Originally posted by Thereisnofuture:
RULES: No resets or Save & Quit abuse (for completing the run without deaths). Deaths are counted only in normal game modes. While the game doesn't count deaths in challenges and dailies, I am going to count them anyway. Intended deaths required for certain achievements aren't counted. Since one the main goals is to minimize the number of deaths, it is acceptable to go to Cathedral/Sheol with the "wrong" Negative/Polaroid to end a run early to avoid death.

Just never mind, it's for sweaties.

Originally posted by Thereisnofuture:
Main updates in Rep+: the Portal to the Void is now guaranteed (you now have 3 attempts to beat Delirium with any character, it can be skipped if your run is not good). It's easier to leave "empty runs" for Dark Room - it gives you more opportunities for "It's the Key"/Victory Laps runs. In addition, due to the Delirium update, it's now preferable to do the very first run to Sheol and the Dark Room as this GUARANTEES saving 20+ minutes, Delirium will still be available two more times, and you won't need to go to the Dark Room again, but it is tedious so you don't need to focus on it, and also you need to keep in mind that it is now more difficult to go to the Dark Room after a Mother run because simple Save & Quit no longer returns you to the same floor. I updated the route because of changes to the 5-win streak achievement (SUDDENLY it really requires streak of 5) and simply rearranged some of the characters, TMTRAINER challenge has also been moved to the group of dull challenges within the first 10-15 hours of the route, where it belongs. Moreover, "fast" achievement pop-ups have been added, which also saves some minutes.
In the patch 1.9.7.13 Plan C was buffed - it can now reliably one-shot Delirium and the second phase of Mother. All in all, Plan C can instantly kill the following: Mother's second phase, Greedier's second phase, Mega Satan's second phase, Beast's final phase, and Delirium; in most cases it's impossible to get to the chest in time afterward, but that doesn’t really matter in a speedrun, that's why it makes sense to unlock it as soon as possible, it will save a lot of time eventually. You can't use Plan C with Lost and T.Lost on the Greedier's second phase and Mega Satan's second phase because they have fast death animation.

Originally posted by Thereisnofuture:
Daily runs: you need a win streak of 5 (you can skip days, but once you start a run, you must complete it, you cannot leave, and you should avoid dying). In total, you need to win 7 daily runs (including the streak) and participate in 31 daily runs overall (after completing the streak and reaching 7 wins, you can simply start and exit the remaining runs without finishing them). If you're doing a speedrun, it's better to skip Sundays, as the goal is always Mega Satan. You can check the character and goal of each daily run in-game on the leaderboard. It's not recommended to play daily runs with the Lost or Judas, as they are easy to die with. It's also best to avoid daily runs where the goal is not Leg or It Lives.

Originally posted by Thereisnofuture:
Victory Laps achievements: it's better to complete the first lap as soon as possible (it unlocks the Gulp! pill which is required for another achievement). As for completing all three Victory Laps, it's better to do them with Tainted Appollyon (if you can do it along the route without extra runs), because he doesn't need items and he keeps all his flies in the laps. Another option is the Lost or any other character who still has a "remaining" run to the Dark Room.

Originally posted by Thereisnofuture:
Examples of useful cut-scene abuses for using R Key/Genesis after Boss fights: Mega Satan - https://www.twitch.tv/videos/1964176251?t=4h3m44s, Beast - https://youtu.be/29U4Ge7xQoE?t=32

Non-linear achievements

Originally posted by Thereisnofuture:

19. A Bandage - Have 4 copies of the Ball of Bandages item at once - Lilith (Box of Friends) or a game break
22. The Book of Sin - Defeat each Deadly Sin mini-boss at least once
23. Little Gish - Defeat Gish in Depths
24. Little Steven - Defeat Steven in Basement
25. Little C.H.A.D - Defeat C.H.A.D. in Caves
27. Halo - Defeat Mom, Mom's Heart, or It Lives! using the Bible active item
30. The Sciccors - Die 100 times
31. The Parasite - Pick up any 2 items from the following list in a run: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head, Guppy's Paw, Guppy's Head, Cricket's Body, etc..
35. Mom's Contact - Obtain three Mom-related items in one run
36. The Necronomicon - Use the "XIII - Death" tarot card 4 times in total
64. Counterfeit Coin - Play the Shell Game beggar and/or the Hell Game beggar 100 times in total
82. The Lost - Die in a Sacrifice Room while holding the Missing Poster trinket
144. Super Meat Boy - Acquire 4 copies of the Cube of Meat item at once in a run (Lilith or a game break)
146. Little Baggy - Acquire two syringe-related items in a run
178. Lord of the Flies - Acquire three fly-related items in one run
258. Blinding Baby - Use the Blank Card while holding the 'XIX - The Sun' consumable (Blank Card + Sun)
324. Sin collector - Complete the Bestiary (acquire all entries)
326. ZIP! - Defeat the Lamb in under 20 minutes
327. It's the Key - Defeat the Lamb without taking any bombs, coins, or hearts throughout the entire run (Normal mode is allowed, Azazel or T.Lilith)
330. U Broke It! - Obtain 50 or more items in total in a single run
337. RERUN - Complete three Victory Laps, and initiate a fourth
353. Bozo - Destroy 5 rainbow poops in total
355. Buddy in a Box - Acquire 5 familiars in a single run
361. Huge Growth - Increase in size by 5 steps from the original size
363. Era Walk - Pick up the Stop Watch and Broken Stop Watch items at least once
366. Moving Box - Use the Pandora's Box active item in the Dark Room
367. Jumper Cables - Pick up two battery-related items in a run
369. Technology Zero - Pick up two Technology(item)-related items in a run
377. Haemolacria - Acquire the Blood Clot passive item 10 times in total
378. Lachryphagy - Collect 10 tears-up items/pill effects in one run
382. Flat Stone - Acquire the Rubber Cement passive item 5 times in total
384. Lil Spewer - Κill yourself with your own Ipecac or Bob's Rotten Head projectile, or the Horf! pill effect
385. Blanket - Sleep in 10 beds in total
386. Marbles - Use the Gulp! pill effect 5 times in a single run
387. Mystery Egg - Spawn three charmed enemies in the same room
389. Baby-Bender - Acquire 2 homing effects in one run (Use the 'I - The Magician' card or the Telepathy for Dummies active item while already having homing tears)
390. The Forgotten - Unlock character
406. The Planetarium - Collect three magic/star-related items in one run (Card related items counts as well)
408. Forgotten Lullaby - Blow up the Siren's skull after defeating it
409. Fruity Plum - Defeat Baby Plum 10 times in total
410. Plum Flute - Spare Baby Plum by not attacking it for 30s
523. Charged Penny - Make Battery Beggars pay out with a pedestal item 5 times in total
545 - Old Capacitor - Kill 10 Battery Beggars
582. Member Card - Spend 40 or more coins in a single Shop
583. Golden Razor - Acquire 99 coins and spend all of them

These are non-linear achievements, so you need to review this list from time to time and try to keep any missing unlocks in mind during your runs. Usually, most of them you will get naturally, or there is a dedicated note about a specific achievement in the route. However, some require constant attention and should be unlocked whenever you have the opportunity. In my opinion, these are:

19. A Bandage - Have 4 copies of the Ball of Bandages item at once - Lilith (Box of Friends) or a game break 144. Super Meat Boy - Acquire 4 copies of the Cube of Meat item at once in a run (Lilith or a game break)

If you didn't get it with Lilith during Boss Rush or the Beast fight, you'll need to reset your Greedier Mode run until you find Ball of Bandages/Cube of Meat in the Greed Shop.

82. The Lost - Die in a Sacrifice Room while holding the Missing Poster trinket

Whenever you find the Missing Poster, immediately sacrifice your run to unlock the Lost. Yes, even if it is the run of your life with every possible Q4-item. Also, whenever you see the Mom's Box in a shop, it's worth buying it for this purpose.

258. Blinding Baby - Use the Blank Card while holding the 'XIX - The Sun' consumable (Blank Card + Sun)

This can also be unlocked during a game break in Greed Mode.

324. Sin collector - Complete the Bestiary (acquire all entries)

This one is a little bit tricky. You don't need to kill every monster, but most of them. Until you unlock this achievement, always take the alt path in your runs to the Beast (both Downpour/Dross and Mines/Ashpit), as there are unique enemies during the ascent.
Also, if your run to Mother is strong, it's better to wait for her special attack in the first phase: she spawns 34 Dead Isaacs. Dead Isaac counts toward the Bestiary achievement.

326. ZIP! - Defeat the Lamb in under 20 minutes

You can complete this on Normal Mode with Azazel or Tainted Lilith, but I recommend doing it during the route with any character that get a strong start. Just don't plan on going for Boss Rush/Hush/Mega Satan.

361. Huge Growth - Increase in size by 5 steps from the original size

You can eat every pill in each run to check if a "One Makes You Larger" pill is in the pool, then do everything you can to maximize pill drops (Placebo, Little baggy, etc.). This is how I got it.
Alternatively, you can play as Lazarus and reset your runs until you find the pill and the rest is the same.
You can also do this with Blank Card + Strength, but you'll need a reliable way to recharge it (e.g., batteries in Greed Mode shops, Sharp plug, etc.). Obviously, you can't leave the room until it's done, because the card's effect lasts only one room. It's easier if you have Tarot Cloth or Magic Mushroom.

386. Marbles - Use the Gulp! pill effect 5 times in a single run

You can eat every pill in each run to check if a "Gulp!" pill is in the pool, then do everything you can to maximize pill drops (Placebo, Little baggy, etc.). This is how I got it.
Alternatively, you can play as Lazarus and reset your runs until you find the pill and the rest is the same.

363. Era Walk - Pick up the Stop Watch and Broken Stop Watch items at least once

366. Moving Box - Use the Pandora's Box active item in the Dark Room

Just stay alert - if you see Pandora's Box in a shop/Curse Room, go to the Dark Room.

382. Flat Stone - Acquire the Rubber Cement passive item 5 times in total

384. Lil Spewer - Κill yourself with your own Ipecac or Bob's Rotten Head projectile, or the Horf! pill effect

When resetting your runs, if you see Ipecac, you can unlock it immediately. Alternatively, if you find a Horf! pill, you can carry it to the end of the run (if it's not a Beast run) and use it to kill yourself there.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

410. Plum Flute - Spare Baby Plum by not attacking it for 30s

523. Charged Penny - Make Battery Beggars pay out with a pedestal item 5 times in total

And these I added from myself:

138. Stop Watch - Donate 999 Coins to the Donation Machine

251. Keeper - Donate 1000 Coins to the Greed Donation Machine

1. Isaac - Sheol

Originally posted by Thereisnofuture:
https://www.youtube.com/watch?v=celW8n7yLtc&list=PLl6ZvhmfR6VdCuAIKk8P8fxPBkFdjZESJ&t=901s&ab_channel=thereisnofuture
The first run is just Isaac on Hard mode. Other options include finding the Shovel to beat Mom's Heart and Sheol to unlock Mom's Knife, or going to the Dark Room after Depth 2 to unlock the Missing Poster and the ability to bomb Angel statues, which is needed for unlocking the Polaroid. You need to skip the first cut-scene in order to continue the run. If you manage to complete both Sheol and the Dark Room in your first run, you can save 20+ extra minutes.

I personally wasn't able to skip the cut-scene even once, so don't get upset if you can't either.

In this run you need to unlock Azazel (for step 6).
Unlock condition: Make 3 Deals with the Devil in one run.
So, it's implied you need to go for Devil rooms in your first run.

I strongly recommend you to do similar first runs in your second and third files right away, even if you haven't decided to go for Infinity yet. You can always decide later, but it allows you to progress daily run achievements on those files as well. Keep in mind that if you play a daily run (doesn't matter if you just enter and quit) you won't be able to play the same daily run on the other files. However, when you complete all daily run achievements on your first file, I am sure you won't have Dead God yet, so you can then start to do dailies on the other files, at least enter-quit ones as they take only a few seconds.

And last but not least regarding daily runs: there is an achievement called "Win Online Daily", which is not addressed in the route. I don't know if it counts toward the 7 daily run wins, but you need to complete it regardless. The earlier, the better.
Main menu - Online - Daily Run - Multiplayer(!!!) - Create lobby (TAB) - Type: Public, Player count/Tag/Password don't matter - Create - [TAB] To Ready (or whatever button under the character is shown if you play with a controller) - Wait 3 seconds for the run to start.
Win Online Daily unlock condition: Win an Online Daily run.
If you didn't get this achievement, go to Main menu - Stats - Secrets, this usually resolves the bug.

2. Ch.3

Originally posted by Thereisnofuture:
Ehwaz

Ehwaz will help you proceed to Sheol after Mom's Heart fight.

Head Trauma is challenge #3.
Isaac starts with Tiny Planet, Soy Milk, The Small Rock, and Iron Bar. The goal is to defeat Mom.

3. Ch.14

Originally posted by Thereisnofuture:
SMB Fan

It's in the Cards is challenge #14.
Isaac starts with Deck of Cards, Starter Deck, The Battery, 9 Volt, and two random tarot cards. The goal is to defeat Mom.

4. Ch.17

Originally posted by Thereisnofuture:
Death's Touch

Waka Waka is challenge #17.
Isaac starts off with Strange Attractor and Anti-Gravity. The goal is to defeat Mom.

5. Ch.18

Originally posted by Thereisnofuture:
Tech.5

The Host is challenge #18.
Isaac starts with Spiderbaby, The Mulligan, and the Tick trinket. The goal is to defeat Mom.

6. Azazel - Greed

Originally posted by Thereisnofuture:
Lilith

According to the route, you have a total of 6 Greed runs (including this one) before Greedier Mode runs begin.
Greedier Mode unlock condition: You must Donate 500 Coins to the Greed Donation Machine.

Ideally, you should donate to the Greed Donation Machine at least 84 coins per Greed run. Aim for a strong start and avoid spending money on the later floors.

7. <3 2

This is the second run to Mom's Heart - or the first if you couldn't manage to skip the cut-scene in your first run. If it's your first Mom's Heart run, it's better to count your Mom's Heart runs to avoid confusion.

You can play any character and mode, but it's fastest with Azazel on Normal Mode.

From this point on, you have a total of 15 runs to Mom's Heart / It Lives! (including this run and your first run, if you skipped the cut-scene) before moving on to a set of very annoying challenges. It's strongly recommended not to unlock the Flooded Caves before then. It's not the end of the world, but can be quite frustrating if unlocked, especially for challenges like Ultra Hard or TMTRAINER.
Unlock condition: The Flooded Caves are unlocked by defeating It Lives! 16 times.

This means that each run to Mom's Heart (steps 7-15) should contribute toward unlocking the Polaroid and the Negative. Obviously, at this point, getting an Angel/Devil Room is the most reliable way to continue your run after the Mom's Heart fight.
Polaroid unlock condition: Defeat Isaac 5 times.
Negative unlock condition: Defeat Satan 5 times.

Polaroid unlock is significantly harder. For the Negative, you can just use "We Need To Go Deeper!" or an Ehwaz rune to reach Sheol. Thus, avoid going to Devil Rooms until you unlock the Polaroid. Obviously, don't give up on the run if a Devil Room spawns after Mom's Heart - just go for Satan. Of course, you can't rely solely on luck, you should manipulate devil/angel deal chances.

If you don't know much about a deal room generation chance, refer to the wiki.gg:
Angel Room[bindingofisaacrebirth.wiki.gg]
Devil Room[bindingofisaacrebirth.wiki.gg]

So, Goat Head, Joker cards, Red Rooms with 5-pip dice on Cathedral/Sheol floors, deal manipulation, and bombing Angel statues are your main tools. For example, from Depth I-II onward, stop getting Angel Rooms (e.g., by taking red heart damage from bosses) to improve your Angel room chances on Womb II. Another obvious way to increase Angle Room chances is by collecting Key Pieces from bombed Angel Statues. Note that if you didn't get to the Dark Room in your first run, you can't bomb Angel statues yet. That's why I recommend prioritizing unlocking Angels.
Angels unlock condition: Complete Chapter 6.

In general, my advice for this run is (in case you didn't unlock angels):

Play as Isaac on Hard Mode
Seek for a strong start
Take advantage of Sacrifice Rooms
Don't kill Mom's Heart to not increase Mom's Heart kill count
Use Sacrifice Rooms on floors 4-6 to reach the Dark Room and kill the Lamb (optionally Mega Satan)
Complete 1 Victory Lap to unlock Gulp! pill

Gulp! pill unlock condition: Once More with Feeling! - Complete a Victory Lap by defeating The Lamb.

In the end of this run, you should have 0 Mom's Heart kills, Angels unlocked, Lamb completion mark for Isaac and Gulp! pill unlocked.

Indeed, ideal scenario is to kill Mom's Heart, get an Angel Room, proceed to the Cathedral, kill Isaac, find a Sacrifice Room on the Cathedral floor and go to the Dark Room to kill Lamb and complete 1 Victory Lap, but, come on, we live in the real world.

8. <3 3

Azazel on Normal Mode.

Track your Mom's Heart kills.

There are 2 achievements called "Play Online" and "Win Online", that also aren't covered in the route. Basically, you need to win a run in Multiplayer. Achievements still count, and you can play solo. So, use one of these Mom's Heart runs to get these achievements.
Main menu - Online - Quick Match - Create New Lobby - Mode: Normal, Player count/Tag/Password don't matter - Create - Select Azazel - [TAB] To Ready (or whatever button under the character is shown if you play with a controller) - Wait 3 seconds for the run to start.
Play Online unlock condition: Play an Online game.
Win Online unlock condition: Win an Online run.
If you didn't get this achievement, go to Main menu - Stats - Secrets, this usually resolves the bug.

9. <3 4

Azazel on Normal Mode.

Track your Mom's Heart kills.

I forgot to say the most important thing: play at your own pace. Don't get discouraged if you don't reach all the goals of a route step in a single run. This route is a recommendation, and it's not a big deal if, for example, you unlock the Polaroid in 20 runs instead of 5. Just take your Ls, get your sh*t together, lock in and repeat the step until it's done before moving on.

10. <3 5

Azazel on Normal Mode.

Track your Mom's Heart kills.

11. <3 6

Azazel on Normal Mode.

Track your Mom's Heart kills.

12. <3 7

Azazel on Normal Mode.

Track your Mom's Heart kills.

13. <3 8

Azazel on Normal Mode.

Track your Mom's Heart kills.

14. <3 9

Azazel on Normal Mode.

Track your Mom's Heart kills.

15. <3 10

Usually Azazel on Normal Mode, but read below.

It's probably not your 10th Mom's Heart kill yet, so you'll need to do more runs to reach 10. You'll need this for step 19, where you will go for Hush.
Hush unlock condition: Defeat Mom's Heart 10 times.

It's highly likely you have already unlocked the Polaroid, and you may need a couple of runs to Sheol to unlock the Negative. If you followed my advice in step 7, you should already have the Lamb completion mark on Isaac, so you need the Satan one. You can use one of the remaining runs as Isaac on Hard Mode to get both Mom's Heart kill and Satan's completion mark.

16. Ch.2

Originally posted by Thereisnofuture:
Jera

High Brow is challenge #2.
Isaac begins this challenge with Number One, E. Coli, Butt Bombs, Flush!, and Petrified Poop. The goal is to defeat Mom.

17. Ch.6

Originally posted by Thereisnofuture:
Perthro

Solar System is challenge #6.
Isaac starts with Distant Admiration, Forever alone, Halo of Flies, and Transcendence. Isaac will also be blindfolded. The goal is to defeat Mom's Heart or It Lives!.

18. Ch.9

Originally posted by Thereisnofuture:
Chaos Card

Demo Man is challenge #9.
Isaac starts with Dr. Fetus, Remote Detonator, and the Match Stick trinket. The goal is to defeat Mom's Heart or It Lives!.

19. Lilith - Hush + Delirium

Originally posted by Thereisnofuture:
https://www.youtube.com/watch?v=ufh3WZXXD1Y&t=23465s&ab_channel=Neonomi
You need to re-enter to the game after completing the Hush in order to proceed to Delirium. If your run is not good, you can beat Delirium in a later run. This unlocks Incubus and Euthanasia.

I personally wasn't able to proceed to Delirium even once, so don't get upset if you can't either. You can beat Delirium in a later run.

You obviously remember, to reach Hush you need to beat Mom's Heart in under 30 minutes.
And, obviously, from now on (this step incl.) everything is played on Hard Mode unless stated otherwise.

20. Polaroid/Negative

If you haven't unlocked them yet, now is the time to do so. If it is the case, you will most likely unlock the Flooded Caves before completing the challenges. Accept it and move on.

21. Ch.23

Originally posted by Thereisnofuture:
Golden Bomb

Blue Bomber is Challenge #23.
The challenge is started as ??? with Kamikaze!, Pyromaniac, Mr. Mega, and Brother Bobby. No Treasure Rooms. The goal is to defeat Satan.

22. Azazel - The Chest (no Boss Rush)

Originally posted by Thereisnofuture:
Maw, Satanic Bible, Abaddon

Even if you have a god-tier run, don't go for Boss Rush. You will aim for the Forgotten unlock with Azazel in step 41, where Boss Rush is inevitable, so don't waste your time on it here.

Also, you must defeat Hush in this run, because in step 25 you are going to Mother and you need to unlock the Alt Path.
Alt Path unlock condition: Defeat Hush 3 times.

23. Ch. 31

Originally posted by Thereisnofuture:
Laz Bleeds More!

Backasswards is challenge #31.
Isaac starts on the Mega Satan boss fight with 8-10 random items and 10 Heart Containers (exact number may vary based on the items). The goal is to play the floors backwards, hence the challenge's namesake. Every floor ascended will cost one Heart Container, and the oldest item in the inventory. The player starts each floor with a boss fight (except the Dark Room, which can be immediately completed), and will have to find the "starting room" to ascend a beam of light to the "previous" floor, (in Repentance and Repentance+) similar to the Ascent.

24. Lazarus - Dark Room (unlock Bethany, no Boss Rush)

Originally posted by Thereisnofuture:
Pandora's Box

Again, even if you have a god-tier run, don't go for Boss Rush - it will unlock Missing No. Also, if you find an R Key or whatever, don't go to the Chest anyway. Defeating Isaac as Lazarus unlocks Lazarus' Rags, which will ruin your Angel Room item pool in many many upcoming runs.

You need to unlock Bethany in this run.
Bethany unlock condition: Defeat Mom's Heart or It Lives! on hard mode as Lazarus, without dying at all
So, don't die.

Also, you must defeat Hush in this run, because in step 25 you are going to Mother and you need to unlock the Alt Path.
Alt Path unlock condition: Defeat Hush 3 times.

Don't forget about this achievement (just reset your run until you find a "One Makes You Larger" pill):

361. Huge Growth - Increase in size by 5 steps from the original size

and about this if you unlocked the Gulp! pill:

386. Marbles - Use the Gulp! pill effect 5 times in a single run

25. Bethany - Mother

Originally posted by Thereisnofuture:
The first run to Mother (be careful, no Holy Mantle). It needs for The Fool card always to be in Depths 2 for challenges. Revelation.

I hope you already know how to reach Mother, but just in case:

Get Knife Piece 1
A white fire place will be present in Downpour / Dross II. Touching the white fire place temporarily transforms Isaac into The Lost. Another room on the floor has a mirror, which Isaac can enter while a ghost. Walking through the mirror will teleport Isaac to the Mirrored World. The Knife Piece is in the Mirrored World's Treasure Room. After acquiring it, Isaac can return to the normal floor by walking through the mirror again.
Get Knife Piece 2
In Mines/Ashpit II, if Isaac has Knife Piece 1, there is a tall room with a broken minecart track. Scattered across the floor are three yellow buttons that will repair pieces of the track. Once all buttons have been pressed, the minecart becomes rideable, which will take Isaac to an abandoned area, with Knife Piece 2 at the end. Picking up the Knife Piece will trigger a chase sequence in which Mother's Shadow will pursue Isaac through the corridor. Getting to the end of the area will seal it off.
Access the Corpse floor
To access The Corpse, the player must first open the flesh door at the end of the Mausoleum/Gehenna II after defeating the Mausoleum version of Mom by doing one of the following:
1) Collect Knife Piece 1 and Knife Piece 2, which are obtained via puzzles inside Downpour and the Mines, to build the knife familiar, and stab the door with it.
2)Sacrifice one key and open the door by using Sharp Key.
3)Cracked Orb can also open the door while simultaneously letting you keep the knife familiar.
4)Using a Soul of Cain.

Don't skip this step, because the next run is to the Beast and you need to unlock A Strange Door.
A Strange Door unlock condition: A Strange Door is a special exit that is unlocked by beating Mother for the first time.

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

26. Eden - Beast

Originally posted by Thereisnofuture:
Early unlock of Challenge 45. First run to Beast.

This is your first run to the Beast so you don't need to leave a trinket in a Boss Room/Treasure Room to unlock Tainted Eden. However, all subsequent runs to the Beast with non-tainted characters imply unlocking tainted counterparts using Cracked Key.

Don't forget to go to the Alt Path for the Sin Collector achievement.

I hope you already know how to reach Beast, but just in case:

A Strange Door is a special exit that is unlocked by beating Mother for the first time. It leads to a special version of Mausoleum/Gehenna II, which contains Dad's Note, which starts the Ascent, and eventually Home and the fight against Dogma and The Beast.

The door spawns in the starting room of Depths/Necropolis/Dank Depths II. It can be opened by giving it The Polaroid or The Negative. This can be done through methods such as using a teleportation card, a Telepills, a teleport activated item, Ventricle Razor, or Forget Me Now after defeating Mom, escaping the boss room. The door can also be opened with Broken Padlock, Cracked Orb, Faded Polaroid, Soul of Cain, or Sharp Key.

It cannot be opened using Mr. ME!, Dad's Key,Mysterious Paper, or a Get out of Jail Free Card.

Having more than one of The Polaroid or The Negative, (such as through Diplopia or R Key) will only remove one to open the door. Faded Polaroid is always taken first if held, then The Negative and then The Polaroid.

A Marked Skull always spawns somewhere in the second floor of the chapter. Destroying it will drop a guaranteed 0 - The Fool (or a Telepills if holding Little Baggy), giving a reliable way to open the door.

If you are at 15 Mom's Heart kills and still wondering whether you will unlock the Flooded Caves, you will. Killing Dogma and The Beast is considered as a Mom's Heart kill.

27. Ch.45

Originally posted by Thereisnofuture:
PREFERABLY do not unlock the Flooded Caves at this point (defeat Heart 16 times). Temperance?

DELETE THIS is challenge #45.
Isaac is the starting character for this challenge, and he starts with TMTRAINER. The goal is to defeat ???.

28. Ch.37

Originally posted by Thereisnofuture:
Sigil of Baphomet

Bloody Mary is challenge #37.
Bethany is the starting character for this challenge, and she starts with Blood Bag, Blood Oath, Anemic, Child's Heart, and The Book of Belial. The goal is to defeat Satan.

29. Ch.36

Originally posted by Thereisnofuture:
Dirty Mind

Scat Man is challenge #36.
Isaac must use friendly Dips and Butt Bombs to defeat enemies. The goal is to defeat Mom.

30. Ch.35

Originally posted by Thereisnofuture:
Greed's Gullet

Pong is Challenge #35.
Isaac starts off with Rubber Cement and Cupid's Arrow. Damage is fixed at 100 and tear rate is fixed at (except in Repentance and Repentance+) 150 / (in Repentance and Repentance+) 0.2. The goal is to defeat ??? in Chest.

31. Ch.34

Originally posted by Thereisnofuture:
Samson Feels Healthy!

Ultra Hard is Challenge #34.
Isaac begins with both halves of the key for the Mega Satan battle and has to beat Mega Satan through the Dark Room.

32. Ch.33

Originally posted by Thereisnofuture:
Charged Key

Pokey Mans is challenge #33.
Isaac starts with Friendly Ball and Mom's Eyeshadow with the objective being to kill Isaac.

33. Ch.32

Originally posted by Thereisnofuture:
Full health pill (Maggy)

Aprils Fool is challenge #32.
Isaac has no special starting items for this challenge. However, all floor bosses are changed to The Bloat, Stonies have a chance to be replaced by Cross Stonies, all items, trinkets, and pickups display an incorrect sprite, activated items and pickups never activate the correct effect, and Isaac's location is displayed as a random room on the map. The goal is to defeat Mom's Heart, which has also been replaced by The Bloat. Treasure Rooms and Shops are present in this challenge.

34. Ch.30

Originally posted by Thereisnofuture:
Clear Rune, Blank Rune

The Guardian is Challenge #30.
Isaac starts blindfolded, with Punching Bag, Isaac's Heart, Holy Grail, and Spear Of Destiny. The goal is to defeat Mom's Heart or It Lives!.

35. Ch.29

Originally posted by Thereisnofuture:
Kidney Stone

Onan's Streak is challenge #29.
Judas starts with The Book of Belial, Chocolate Milk, and a damage bonus of +2, giving him a starting damage of 8.71. However, missing a shot causes Judas to take damage. Treasure rooms are present in this challenge. The goal is to defeat Isaac.

36. Ch.28

Originally posted by Thereisnofuture:
D8

PRIDE DAY! is challenge #28.
Isaac starts with Rainbow Worm, 3 Dollar Bill, and Rainbow Baby. The goal is to defeat Mom's Heart or It Lives!.

37. Ch.22

Originally posted by Thereisnofuture:
Get out of Jail Free Card

SPEED! is Challenge #22.
In this challenge, all enemies are sped up as if under the "speed up" effect of the Broken Watch. Isaac also has greatly increased movement speed. The goal is to defeat Mom's Heart or It Lives! with a "soft" time limit of 16 minutes.

38. Ch.21

Originally posted by Thereisnofuture:
Gold Heart

XXXXXXXXL is Challenge #21.
This challenge changes all floors to be the size of XL Womb but does not combine the floors of each chapter. The goal is to defeat Mom's Heart / It Lives!.

39. Ch.19

Originally posted by Thereisnofuture:
Epic Fetus

The Family Man is challenge #19.
Isaac starts with Brother Bobby, Sister Maggy, Rotten Baby, BFFS!, and Dad's Key. However, he is also blindfolded and must instead rely on familiars to do damage. The goal is to defeat Isaac.

40. Ch.10

Originally posted by Thereisnofuture:
Credit Card

Cursed! is challenge #10.
Magdalene is the starting character for this challenge, and she starts with Yum Heart, Raw Liver, The Compass, Treasure Map, Blue Map, and Child's Heart. Every floor is cursed with Curse of the Cursed. The goal is to defeat Mom.

41. Azazel - Dark Room (unlock Forgotten)

Surely, you know how to unlock Forgotten, but just in case:

First, defeat the first floor's boss within 1 minute. If done correctly, Mom will yell and the sound of running footsteps will play, then a large shadow of a shovel handle will loom over the floor of the starting room. Bombing anywhere in the starting room will spawn the Broken Shovel. Initially the shovel piece behaves like a pickup, laying on the floor, and turns into an active collectible only when touched for the first time. Holding the Broken Shovel will cause Mom to continually try to stomp Isaac. Using the Broken Shovel will stop the stomping for the current room, but will only stop the stomping for the current boss wave in the Boss Rush.
Next, clear Boss Rush. This will grant the second piece of the Broken Shovel, completing Mom's Shovel. The Broken Shovel must be held when the boss rush is beaten. Otherwise, only a normal boss rush completion item will drop.
Finally, a single Grave Room with a Dirt Patch in its center will appear in the Dark Room. Using Mom's Shovel while standing on the Dirt Patch unlocks The Forgotten.

I hope you remember that if you have the Broken Shovel, you don't need to meet the 20-minute Boss Rush requirement. While you are holding the item the door to the Boss Rush will always be open.

42. Blue Baby - The Chest

Originally posted by Thereisnofuture:
D6 for Isaac.

Whenever you see The Chest or The Dark Room as the goal, it's implied you should complete Boss Rush, Hush, Mega Satan and Delirium, unless exlicitly stated otherwise. It's usually better to complete these marks during a Chest run, because it gives you more opportunities to complete ZIP!, It's the Key or RERUN achievements during your runs to the Dark Room.
You can also complete Boss Rush during Mother and Beast runs. Keep in mind that Delirium transforms into bosses previously encountered during the run, so if complete Boss Rush, you need to be confident in your build before attempting Delirium.

General template is as follows:

The Chest: Boss Rush, Hush, Isaac, ???, Mega Satan
The Dark Room: Satan, Lamb, Delirium optionally
Mother: Mother, Delirium
Beast: Beast

Remember! It's just my recommendation. If you are not an experienced player then just complete Boss Rush/Hush/Delirium whenever you have an opportunity, but don't forget to track your missing completion marks.

43. Isaac - All

Originally posted by Thereisnofuture:
Missing Poster

All missing completion marks EXCEPT Ultra Greed.

44. Judas - Dark Room/Beast (no Boss Rush)

Originally posted by Thereisnofuture:
Curved Horn

Run to the Dark Room AND the Beast.

45. Bethany - Dark Room, Delirium

Originally posted by Thereisnofuture:
Urn of Souls, Star of Bethlehem

46. Lilith - All (no Mother)

Originally posted by Thereisnofuture:
Succubus, Euthanasia, C Section

All completion marks EXCEPT Mother and Ultra Greed.

47. TLilith - All

Originally posted by Thereisnofuture:
Twisted Pair, Gello, Soul of Lilith

All completion marks EXCEPT Ultra Greed.

I recommend you to get ZIP! achievement during your run to the Dark Room. Reset until you find really strong start.

326. ZIP! - Defeat the Lamb in under 20 minutes

48. Jacob - All

Originally posted by Thereisnofuture:
Rock Bottom, Red Stew, The Stairway, Damocles, Birthight

All completion marks EXCEPT Ultra Greed.

49. Eden - The Chest

Originally posted by Thereisnofuture:
Jumping to the chest is mandatory! Blank Card, Mysterious Paper (can help with unlocking the Lost), Eden's Soul.

Never mind words about jumping to the chest. Sweaty guys usually don't bother watching endings - after getting a completion mark, they exit the run and start a new one as soon as possible. I am sure you always jump to chests, but if not, this one is important because it counts toward the 5 Nights at Mom's achievement.

50. Samson - Greed no reset

Originally posted by Thereisnofuture:
No resets. Complete the 5-win streak achievement. Lusty Blood.

NO RESETS. Doing the 5 Nights at Mom's achievement.

Also, don't forget to donate at least 84 coins to the Greed Donation Machine in the end.

51. Lilith - Greed no reset

Originally posted by Thereisnofuture:
As an option, you can reset runs until you find Ball of Bandages in a shop to unlock A Bandage.

NO RESETS. Doing the 5 Nights at Mom's achievement.
As regards A Bandage/Super Meat Boy achievements, you can unlock them during your Greedier run.

Also, don't forget to donate at least 84 coins to the Greed Donation Machine in the end.

52. TLilith - Greed no reset

NO RESETS. Doing the 5 Nights at Mom's achievement.

Also, don't forget to donate at least 84 coins to the Greed Donation Machine in the end.

53. TJacob - Greed no reset

NO RESETS. Doing the 5 Nights at Mom's achievement.

Also, don't forget to donate at least 84 coins to the Greed Donation Machine in the end.

54. Isaac - Greed

NO RESETS. Doing the 5 Nights at Mom's achievement.

Also, don't forget to donate at least 84 coins to the Greed Donation Machine in the end.

55. Isaac - Greedier

Originally posted by Thereisnofuture:
On this step, under ideal conditions, The Greedier Mode should already be unlocked (500 coins). Definitely avoid playing as Maggy or Bethany. D1.

So, if you haven't unlocked Greedier Mode yet, you should do so with a character which you haven't play before (because they have 0% jam chance). Don't play as Magdalene and Bethany.

56. Lazarus - Greedier

Originally posted by Thereisnofuture:
Plan C

57. Apollyon - Greedier

Originally posted by Thereisnofuture:
Black Rune

58. Jacob - Greedier

Originally posted by Thereisnofuture:
Genesis

59. TJacob - Greedier

Originally posted by Thereisnofuture:
Sun?, The Moon?

60. TJudas - Greedier

Originally posted by Thereisnofuture:
Do this only if you haven't unlocked Holy Mantle for the Lost yet. You can skip unlocking the Keeper at this point.

I recommend you to do this anyway.
Lost holds Holy Mantle unlock condition: Donate 879 Coins to the Greed Donation Machine.
Keeper unlock condition: Donate 1000 Coins to the Greed Donation Machine.

61. *Cain - Greedier

I recommend you to do this anyway.
Lost holds Holy Mantle unlock condition: Donate 879 Coins to the Greed Donation Machine.
Keeper unlock condition: Donate 1000 Coins to the Greed Donation Machine.

62. *Blue Baby - Greedier

I recommend you to do this anyway.
Lost holds Holy Mantle unlock condition: Donate 879 Coins to the Greed Donation Machine.
Keeper unlock condition: Donate 1000 Coins to the Greed Donation Machine.

63. *Samson - Greedier

I recommend you to do this anyway.
Lost holds Holy Mantle unlock condition: Donate 879 Coins to the Greed Donation Machine.
Keeper unlock condition: Donate 1000 Coins to the Greed Donation Machine.

64. Ch.8

Originally posted by Thereisnofuture:
Algiz

Cat Got Your Tongue is challenge #8.
Isaac starts this challenge with Guppy's Head, Guppy's Tail, and Guppy's Hairball, as well as three Soul Hearts and three Black Hearts, as well as his usual three Red Heart containers. Isaac is also blindfolded. This challenge is unlocked by transforming into Guppy. The goal is to defeat Mom.

65. Ch.13

Originally posted by Thereisnofuture:
Burnt Penny

Beans! is challenge #13.
Isaac starts off with Pyro, The Bean, The Black Bean, 9 Volt, and Butt Bombs. The goal is to defeat Mom.

66. Ch.15

Originally posted by Thereisnofuture:
Swallowed Penny

Slow Roll is challenge #15.
Isaac starts with Polyphemus, Cupid's Arrow, and My Reflection. Damage is fixed at 100, shot speed is fixed at 1.0 and fire rate is at 0.49 tears per second (60 tear delay). The goal is to defeat Mom.

67. Ch.16

Originally posted by Thereisnofuture:
Robo Baby 2.0

Computer Savvy is challenge #16.
Isaac starts off with Technology, Technology 2, and Spoon Bender. The goal is to defeat Mom.

68. Ch.27

Originally posted by Thereisnofuture:
Stud Finder

BRAINS! is Challenge #27.
This challenge is played as ??? and you start blindfolded, with 3 Bob's Brain, Thunder Thighs and (in Repentance and Repentance+) the Bob transformation. The goal is to defeat ???.

69. Ch.40

Originally posted by Thereisnofuture:
Broken Glasses

Seeing Double is challenge #40.
The goal is to defeat Mom's Heart.

70. TIsaac - All

Originally posted by Thereisnofuture:
The Stars?, Glitched Crown, Soul of Isaac, Spindown Dice

From now on, "All" means all completion marks INCLUDING Ultra Greedier!.

71. Cain - Blue Baby, Mother

Originally posted by Thereisnofuture:
Guppy's Eye

Blue Baby means The Chest (Isaac, ???, etc.).

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

72. TJudas - No Beast

Originally posted by Thereisnofuture:
Dark Arts, Black Sack

All completion marks EXCEPT Beast.

73. Eve - The Chest, Beast

Originally posted by Thereisnofuture:
Cracked Orb

74. TEve - All

Originally posted by Thereisnofuture:
Sumptorium, Heartbreak

75. Forgotten - All

Originally posted by Thereisnofuture:
Divorce Papers, Pointy Rib, Brittle Bones, Dad's Ring, Book of the Dead

76. Samson - Beast

Don't forget to go through the Alt Path if the Sin Collector achievement isn't unlocked.

77. TSamson - All

Originally posted by Thereisnofuture:
Berserk!, Larynx

78. Blue Baby - Mother, Beast

Originally posted by Thereisnofuture:
Eternal D6, Montezuma's Revenge

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

79. TBlue Baby - All

80. Lazarus - Beast

Don't forget to go through the Alt Path if the Sin Collector achievement isn't unlocked.

Don't forget about this achievement (just reset your run until you find a "One Makes You Larger" pill):

361. Huge Growth - Increase in size by 5 steps from the original size

and about this if you unlocked the Gulp! pill:

386. Marbles - Use the Gulp! pill effect 5 times in a single run

81. TLazarus - All

Originally posted by Thereisnofuture:
Soul of Lazarus, Judgement?, Flip, Salvation

82. Maggy - Beast

Originally posted by Thereisnofuture:
Maggy's Bow

83. TMaggy - All

Originally posted by Thereisnofuture:
Mother's Kiss, Lovers?

84. TJacob - All

Originally posted by Thereisnofuture:
Anima Sola, Esau Jr.

85. Keeper - All

Originally posted by Thereisnofuture:
Keeper's Sack

The order should be:

The Chest (with Hush)
Keeper holds Wooden Nickel unlock condition: Defeat Isaac as Keeper.
Keeper now holds... A Penny! unlock condition: Defeat Hush as Keeper.
The Dark Room
Keeper holds Store Key unlock condition: Defeat Satan as Keeper.
The rest completion marks

86. TKeeper - All

87. The Lost - All (It's the Key)

Originally posted by Thereisnofuture:
Preferably complete the "It's the Key" achievement with the Lost. It's better to leave Victory Laps (if not yet completed) for another character, because the Lost can't use Sacrifice Rooms. However, you can do it if you have a strong desire and a shovel/teleport cards. The Mind, Godhead.

Try to complete "It's the Key" achievement along your run to the Dark Room.

Unlock condition: Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run. Letting certain familiars (e.g. Bum Friend, Dark Bum, Bumbo or Lil Portal) or bosses (e.g. Bumbino) pick up the consumables fails this condition as well.

What is allowed:

Keys (doubled, gold, charged)
Tarot cards
Runes
Pills
Items (even those that give you pickups like Pay To Play)

What isn't allowed:

Hearts
Bombs
Coins

Alternatively, you can get all completion marks with the Lost and then just start a new run on Normal Mode to complete "It's the Key" achievement. This is how I did it.

88. TLost - All

Originally posted by Thereisnofuture:
Sacred Orb

89. Maggy - Dark Room

Originally posted by Thereisnofuture:
Guardian Angel, Eucharist

90. Lilith - Mother

Originally posted by Thereisnofuture:
Stupid dog (Blood Puppy)

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

91. Apollyon - All

Originally posted by Thereisnofuture:
L O C U S T S

92. Ch.4

Originally posted by Thereisnofuture:
Dagaz

Darkness Falls is challenge #4.
Eve is the default character for this challenge, and she starts the challenge with Pentagram, Dead Bird, ♥♥♥♥♥ of Babylon, Razor Blade, Sacrificial Dagger, and Dark Matter. The goal is to defeat Satan.

93. Ch.5

Originally posted by Thereisnofuture:
Ansuz

The Tank is challenge #5.
Magdalene is the default character for the challenge, and she starts with Bucket of Lard, Infamy, Yum Heart, and Thunder Thighs. The goal is to defeat Mom.

94. Ch.20

Originally posted by Thereisnofuture:
Rune of Berkano

Purist is challenge #20.
This challenge is unique because Isaac starts with no items. The goal is to defeat Mom's Heart or It Lives!.

95. Ch.24*

Originally posted by Thereisnofuture:
If you have already completed the Marbles achievement.

PAY TO PLAY is Challenge #24.
In this challenge, Isaac starts with 50 coins, Money = Power, and the Sack of Pennies. However, every doorway is now an arcade door, and taking any damage will cause Isaac to lose more pennies than can be picked up, similar to when being attacked by Greed. Having 0 pennies will kill him and end the challenge. The goal is to defeat Isaac.

96. Ch.26

Originally posted by Thereisnofuture:
Poker Chip

I RULE! is challenge #26.
Isaac starts off with Key Piece 1, Key Piece 2, Trinity Shield, Mom's Knife, The Ladder, and The Boomerang. The goal is to defeat Mega Satan.

97. Ch.38

Originally posted by Thereisnofuture:
Purgatory

Baptism by Fire is challenge #38.
The goal is to defeat Isaac.

98. Ch.41*

Originally posted by Thereisnofuture:
If you have already completed Marbles, do this challenge as soon as possible = less garbage in the trinket pool.

Pica Run is challenge #41.
The goal is to defeat Isaac.

99. Ch.42

Originally posted by Thereisnofuture:
The Chariot?

Hot Potato is challenge #42.
The player starts as a blindfolded Tainted Forgotten. The Forgotten explodes every 2.5 seconds, capable of dealing friendly damage to The Soul. The goal is to defeat Satan.

100. Ch.44

Originally posted by Thereisnofuture:
The Hermit?

Red Redemption is challenge #44.
Tainted Jacob starts with Dad's Key and Red Key. After using the Red Key 20 times on a single floor, Dark Esau will spawn. The Red Key's charge bar displays how many uses it has left until this happens, rather than the item's actual charge. Another Dark Esau will spawn every 5 additional uses of the Red Key, as long as Jacob is not in his The Lost form. If he is, no more Dark Esaus will spawn. The goal is to defeat Mother.

101. Cain - All

102. Ch.43

Cantripped! is challenge #43.
In this challenge, you play as Tainted Cain, but instead of crafting items from pickups using your Bag of Crafting. The goal is to defeat Mom.

In Repentance+ 1.9.7.15 this challenge was bugged af. If you had Item Descriptions enabled, the game would crash after using the first item card. This was "fixed" in 1.9.7.16 by disabling Item Descriptions. As of now - 1.9.7.17 - I haven't tested it, but if you have troubles, try disabling Item Descriptions.

103. TCain - All

Originally posted by Thereisnofuture:
Soul of Cain

104. TApollyon - All (RERUN)

Originally posted by Thereisnofuture:
Complete the RERUN achievement if it's still locked.

105. TForgotten - All

If you haven't picked up Birthright as Tainted Forgotten, you must reset your Greedier! runs until you find this item in the shop. It gives the pocket item Recall, which will pull Tainted Forgotten into Tainted Soul's hands regardless of distance. For some unknown reason this pocket item counts toward the Collection and you won't get Dead God without it. I learnt it the hard way.

106. Judas - All

107. TJudas - Beast

108. Samson - All

Originally posted by Thereisnofuture:
Bloody Lust

109. Bethany - Chest, Beast

110. TBethany - All

111. Azazel - All

112. TAzazel - All

113. Maggy - The Chest, Mother

Originally posted by Thereisnofuture:
A Cross, Celtic Cross

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

114. Blue Baby - Dark Room

Originally posted by Thereisnofuture:
Forget Me Now

115. Eve - Dark Room, Mother

Originally posted by Thereisnofuture:
Razor Blade

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

116. Lazarus - The Chest, Mother

Originally posted by Thereisnofuture:
Lazarus' Rags

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

Don't forget about this achievement (just reset your run until you find a "One Makes You Larger" pill):

361. Huge Growth - Increase in size by 5 steps from the original size

and about this if you unlocked the Gulp! pill:

386. Marbles - Use the Gulp! pill effect 5 times in a single run

117. Eden - Dark Room, Mother

Also, you are going to Mausoleum where you can encounter the Siren boss. Don't forget about the Forgotten Lullaby achievement.

408. Forgotten Lullaby - Blow up the Siren's skull after defeating it

118. Maggy - Greedier

119. Eve - Greedier

120. Eden - Greedier

121. Lilith - Greedier

19. A Bandage - Have 4 copies of the Ball of Bandages item at once 144. Super Meat Boy - Acquire 4 copies of the Cube of Meat item at once in a run

Remember about these achievements if they aren't unlocked yet. Reset your runs until you find Ball of Bandages/Cube of Meat in the Greed Shop.

122. Bethany - Greedier (Mega Mush)

123. TLilith - Greedier

124. Die 100 times

Originally posted by Thereisnofuture:
Tainted Lost (Greed mode)

If you want a nice, round number of 100 on your stats page, you need to do this after step 125.

125. TEden - All

Originally posted by Thereisnofuture:
At this point, the goal is to get as MAXIMUM items as possible and reroll them as MAXIMUM times as possible for collecting missing items before performing a game break at the end of the route. It's better to go through both Angel Rooms and Devil rooms if possible. In addition, it's always worth to skip cut-scenes (even if there is no continuation of the run) and reroll you build if you have enough bombs and HP. D4 bug, sadly, no longer works.

126. Ch.39

Originally posted by Thereisnofuture:
Spirit Sword

Isaac's Awakening is challenge #39.
Isaac starts with Spirit Sword, Trinity Shield, and Mom's Bracelet. The goal is to defeat Mother.

127. Breaking

Originally posted by Thereisnofuture:
Perform a game break in Greed Mode with Azazel, because we only need D20 but clearing floors with other characters is significantly slower. Here, we can complete the 5 Gulp! Achievement if it's still locked - even if there is no Gulp! pill in the pool of your run, the achievement is 100% unlockable with a golden pill, however, it is very important to have a second slot available for a teleport card or an active item if you use a golden pill, as there is a high risk of being telepilled to the Error Room.

The purpose of this step is to collect items you haven't touched in the game. You can use one of the tools I described in the "Introduction notes" section to see which items you are missing. Alternatively, you can go to Main Menu - Stats - Items and compare it manually with the Collection page[bindingofisaacrebirth.wiki.gg].

I couldn't find compehensive info online about the all required items, so here is my understanding based on personal experience (as of April 2026, patch 1.9.7.17):
You should see 722 items on the Main Menu -> Stats page to ensure everything is completed:

There are 717 items on the collection page that you need to pick up in-game to obtain Dead God (daily runs and challenges don't count);
Another 2 items, as I undestand, are hidden and unlocked by default, you don't need to worry about them;
Another 1 - G FUEL! - is also unobtainable. It's for special seed and dailies, unlocked by default, you don't need to worry about it;
Another 1 - Hold - is the starting item of Tainted ???, it's unlocked when you play the character, you don't need to worry about it;
The last 1 - Recall - is an item you get when you pick up Birthright as Tainted Forgotten. I already mentioned this in the relevant section. So, once again, to unlock it, you must pick up Birthright, while playing Tainted Forgotten.

717 + 2 + 1 + 1 +1 = 722. In general, 717 items on the collection page and Recall are the only things you need to keep your eye on.

If you have never done a game break in Greed Mode, it’s best to watch a quick video guide. Basically, you only need D20 or D Infinity and a battery in the shop. It's much more efficient to spend a couple of minutes watching a video to understand how it works and how to take advantage of it to get the items you need.

If you are going to reset your run a million times anyway to find D20/D Infinity, then you can try to unlock the Blinding Baby achievement if it's still locked. If you see Blank Card in the shop, buy it, then spend your money on cards until you find XIX - The Sun.

258. Blinding Baby - Use the Blank Card while holding the 'XIX - The Sun' consumable (Blank Card + Sun)

128. Ch.1

Originally posted by Thereisnofuture:
Hagalaz

Pitch Black is challenge #1.
During this challenge, Curse of Darkness and Curse of the Unknown will be permanently active. Unlike other challenges, Treasure Rooms are available, but Shops are not. The goal is to defeat Mom.

129. Ch.7

Originally posted by Thereisnofuture:
Suicide King

Suicide King is Challenge #7.
Lazarus is the default character for this challenge, and he starts with Ipecac, Mr. Mega and My Reflection, as well as a random pill. The goal is to defeat Isaac.

130. Ch.11

Originally posted by Thereisnofuture:
Rules Card

Glass Cannon is challenge #11.
Judas is the default character in this challenge, and he starts with Epic Fetus and Loki's Horns. The goal is to defeat Satan.

131. Ch.12

Originally posted by Thereisnofuture:
Card Against Humanity

When Life Gives You Lemons is challenge #12.
Isaac is the default character for the challenge, and he starts with Lemon Mishap, 9 Volt, Habit, and a Lemon Party pill. The goal is to defeat Mom.

132. Ch.25

Originally posted by Thereisnofuture:
2 new pills

Have a Heart is challenge #25.
Isaac begins with Charm of the Vampire and 12 red heart containers, but only one of them is filled. Unlike in many other challenges, Treasure Rooms and Shops are available. The goal is to defeat Mom's Heart / It Lives!.

133. Dead God

МОИ ПОЗДРАВЛЕНИЯ!

Who tf I am

I am just a casual player who achieved Infinity using this route. I didn't use mods, external apps, the console, or whatever bs some players use to justify cheating.

First Dead God: 488 hours (No resets, no giving up on runs)
Second Dead God: 268 hours
Third Dead God: 205 hours

If you are interested, for some reason, you can follow me on twitch[www.twitch.tv]. I mostly stream in Russian, but if you message me in English, we can talk. Keep in mind that I am not going to play Isaac anymore.

If you are a fellow achievement hunter, feel free to add me.

Feedback and Updates

I will be maintaining this guide for the next couple of weeks, so any errors, misspellings, misinformation, or general feedback are greatly appreciated!

The Binding of Isaac: Rebirth